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EDUCATION B. S. Chemical Engineering, National Taiwan University, 1957 M. A Organic Chemistry, Temple University, 1960 Ph. D. Molecular Biology, Purdue University, 1968
RESEARCH AND/OR PROFESSIONAL EXPERIENCE Senior Research Scientist and Group Leader of Molecular Genetics Group, LORRE, July 1, 1980 to present. Graduate Faculty, Department of Foods & Nutrition, Purdue University, Sept.1, 1982 to present
HONORS, RECOGNITIONS, AND OTHER AWARDS 1998 R&D 100 Award from R&D Magazine for her successful development of the genetically engineered Saccharomyces yeast that can effectively co-ferment both glucose and xylose from cellulosic biomass, which has made biomass-to-ethanol technology closer to commercialization. The Chicago Tribune has called this award “The Oscar of Invention.” Others have referred to the award as “the Nobel Prize of Applied Research.” In these two years, numerous news organizations carried the news about Dr. Ho's work on the development of the recombinant yeasts that can convert sugars from all forms of cellulosic materials to ethanol to be used to replace or substitute gasoline. 1999 The genetically engineered Saccharomyces yeasts developed by Dr. Ho were also honored by Discover Magazine as one of 27 of the most important technological innovations of 1999 selected from more than 4000 technological innovations worldwide. Dr. Ho was honored by Discover Magazine as one of the 27 finalists of the Discover Award for that year. 2004 Since April 2004 , Iogen, a Canadian company, has used the engineered yeast developed by Dr. Ho at Purdue University to produce ethanol from wheat straw in the world‘s first production plant of its kind. Purdue University issued a news release on June 28, 2004 entitled, Purdue yeast makes ethanol from agricultural waste more effectively, to mark this special event. Many newspapers and magazines have also reported upon this exciting development. PATENTS RELATED TO GENETIC ENGINEERING OF YEASTS FOR NEW INDUSTRIAL APPLICATIONS Ho, N. W. Y and G. T. Tsao. "Recombinant Yeasts for Effective Fermentation of Glucose and Xylose, PCT Patent No. W095/13362, (1995); the patent was allowed in the US on Aug. 4, 1998, patent No. 5, 789,210. Ho, N. W. Y, and Chen, Z. D., "Stable Recombinant Yeasts Capable of Effective Fermentation of Both Glucose and Xylose." Patent Application, #60/016, 865, May 6, 1996. PCT Patent No. WO97/42307, November 13, 1997. This application has been allowed in Australia before March, 2001 but pending everywhere else including US. Ho, N. W. Y. and Miroslav Sedlak, “Development of Stable Genetically Engineered Yeast for Industrial Conversion of Sugars from Glucose-Based and Glucose-Xylose- Based Feedstocks to Lactic Acid”, patent pending.
PUBLICATIONS Sedlak, M. and N. W. Y. Ho, “Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast,” Yeast 21:671-684, 2004. Sedlak, M. and Ho N.W.Y., "Production of ethanol from cellulosic biomass hydrolysate using genetically engineered Saccharomyces yeast capable of co-fermenting glucose and xylose", Appl. Biochem. Biotech. 113-116: 403- 416 (2004). Nancy W. Y. Ho, “The logical design and development of genetically engineered yeast for effective conversion of plant cellulosic biomass to ethanol”, in Chinese Americans in Science and Technology pp 85-132, Outer Sky Press, New York, 2003. Sedlak M, Edenberg H.J. and Ho N.W.Y., "DNA microarray analysis of the expression of the genes encoding major enzymes in ethanol production during glucose and xylose co-fermentation by metabolically engineered Saccharomyces yeast", Enzyme. Microbial. Technol. 33:19-28, 2003. D. Sliva, C. Labarrere, V. Slivova, M. Sedlak, F. P. Lloyd Jr., N. W. Y. Ho, "Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells", BBRC. 298, 603-612, 2002. Sedlak, M., and N. W. Y. Ho, “Expression of E. coli araBAD operon encoding enzymes for metabolizing L-arabinose in Saccharomyces cerevisiae,” Enzyme and Microbial Technology , 28 , 16-24 (2001). Ho, N. W. Y., Z. Chen, A. P. Brainard, and M. Sedlak, Chapter 12 in ACS Symposium Series 767 , “Genetically engineered Saccharomyces yeasts for conversion of cellulosic biomass to environmentally friendly transportation fuel ethanol,” Amer Chem Society, 142-159 (2000). Ho, N.W.Y., Z. Chen, A. P. Brainard, and M. Sedlak, “Successful design and development of genetically engineered Saccharomyces yeasts for effective cofermentation of glucose and xylose from cellulosic biomass to fuel ethanol,” Advances in Biochemical Engineering/Biotechnology , 65 , 163-192 (1999). Ho, N. W. Y., Z. Chen, and A. Brainard, “GeneticallyeEngineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose,” Appl Environ. Microbiol, 64 , 1852-1859 (1998). Toon, S. T., G. P. Philippidis, N. W. Y. Ho, Z. Chen, A. Brainard, R. E. Lumpkin, and C. J. Riley, “Enhanced cofermentation of glucose and xylose by recombinant Saccharomyces yeast strains in batch and continuous operating modes,” Appl. Biochem. and Biotech ., 63-65 , 243-255 (1997). Moniruzzaman, M., B. S. Dien, C. D. Skory, Z. D. Chen, R. B. Hespell, N. W. Y. Ho, B. E. Dale, and R. J. Bothast, “Fermentation of corn fibre sugars by an engineered xylose utilizing Saccharomyces yeast strain,” World Journal of Microbio & Biotechno 13 , 341 (1997). Cao, N. J., Krishnan, M. S., Du, J. X., Chen, Z. D., Gong, C. S., Ho, N. W. Y. and Tsao, G. T., “Ethanol production from corn cob pretreated by the ammonia steeping process using genetically engineered yeast,” Biotechnology Letters , 18, 1013-1018, 1996. Ho, N. W. Y., and S. -F. Chang, "Cloning of yeast xylulokinase gene by complementation of E. Coli and yeast mutations," Enzyme Microb. Technol., 11 , 417-421 (1989). Stevis, P. E. and N. W. Y. Ho, "Construction of yeast xylulokinase mutant by recombinant DNA techniques," Appl. Biochem. Biotechnol. , 20 (21), 327-334 (1989). Chang, S. F. and N. W. Y. Ho, "Cloning the yeast xylulokinase gene for the improvement of xylose fermentation," Appl. Biochem. and Biotechnol. , 17, 313-318 (1988). Rosenfeld, S., P. Stevis, G. T. Tsao, and N. W. Y. Ho, "Genetic characterization of the xylose utilization genes of E. coli ," Mol. Gen. Genetics, 410-415 (1984). Stevis, P. E., J. J. Huang, and N. W. Y. Ho, "Cloning of the Pachysolen tannophilus xylulokinase gene by complementation in Escherichia coli," Appl. Environ. Microbiol., 53(12), 2975-2977 (1987). Stevis, P. E. and N. W. Y. Ho, "Overproduction of D-Xylose isomerase in E. coli by cloning the D-Xylose isomerase gene," Enzyme Microbial Technology, 7, 592-596, (1985). Rosenfeld, S., P. Stevis, G. T. Tsao, and N. W. Y. Ho, "Genetic characterization of the xylose utilization genes of E. coli ," Mol. Gen. Genetics , 410-415 (1984). |
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