WON LABORATORY AT PURDUE UNIVERSITY

 

POLYMERS & NANOBIOMATERIALS

 

HISTORY & MISSION

 

Won Laboratory specializes in fundamental polymer science and preclinical proof-of-concept research directly related to the clinical applications of polymeric nanomaterials.

 

During Professor Wonʹs PhD and postdoctoral studies from the late 1990s to the early 2000s, his research primarily focused on the study of non-equilibrium block copolymer self-assemblies in both aqueous and non-aqueous media. This included the investigation of polymer wormlike micelles as well as polymer vesicles, also known as ʺpolymersomesʺ.

 

Since the mid-2000s to the mid-2010s, research conducted in Professor Won's laboratory at Purdue University centered around polyelectrolytes. More specifically, the focus was on studying the charge regulation behavior of weak polyelectrolytes and exploring their applications in gene/siRNA delivery, as well as the manipulation of charged colloids. Won Lab was one of the first research groups to demonstrate the concept of ʺmicelleplexesʺ, which are complexes formed between positively charged block copolymer micelles and negatively charged DNA/RNA molecules.

 

Since the mid-2010s, Won Laboratory has shifted its efforts towards prioritizing the direct societal impact of their work while still addressing fundamental scientific problems. Won Lab is currently focused on three specific areas:

1.     Conducting studies on the air-water interfacial behavior of block copolymer micelles, with the goal of developing Polymer Lung Surfactnat (PLS) therapy for the treatment of respiratory distress syndrome.

2.     Developing and conducting proof-of-concept studies on block copolymer-encapsulated radioluminescent nanoparticle formulations, aimed at enhancing cancer radiotherapy. This approach is named as Radioluminescence Therapy.

3.     Engaging in the development and fundamental studies of statistically sequence-controlled aliphatic copolyesters, including uniform poly(lactic-co-glycolic acid) (PLGA), for the creation of next-generation long-acting controlled-release drug formulations.

These areas of focus reflect Won Laboratoryʹs commitment to addressing practical societal needs and advancing scientific knowledge through their research activities. Credit for these advancements is attributed to all current and former members of the group.

 

REFEREED JOURNAL PUBLICATIONS

 

1)         Seong Hwan Kim, Yoon Huh, Baek Sung Park, Kevin Injoe Jung, You-Yeon Won, Joona Bang, Hyun Wook Jung, ʺEnhancing Air-Water Interfacial Adsorption of Suspended Particles Suppresses Coffee Ring Formation: Diffusing Wave Spectroscopy and Visual Analysis of Drying Sessile Drop Suspensions Containing Silica Particles Coated with Thermo-Responsive Poly(methyl methacrylate-b-N-isopropylacrylamide) Block Copolymersʺ, submitted, 2024.

 

2)         SeongHoon Jo, Soonjong Roh, Jaemin Shim, Jiwoong Yu, Youngmee Jung, Woo Young Jang, Bumjoon Seo, You-Yeon Won, Jin Yoo, ʺModulating Thermo-Responsive Characteristics of PLGA-PEG-PLGA Hydrogels via Manipulation of PLGA Monomer Sequencesʺ, submitted, 2024.

 

3)         Samruddhi M. Patil, You-Yeon Won, ʺEffect of Monomer Sequence Distribution on the Glass Transition Temperature of Poly(D,L-lactic-co-glycolic acid) (PLGA)ʺ, Macromolecules under revision, 2024.

 

4)         Taesuk Jun, Daniel J. Fesenmeier, You-Yeon Won, ʺSurface Mechanical Behavior of Water-Spread Poly(styrene)-Poly(ethylene glycol) (PS-PEG) Cylindrical Micelles at the Air-Water Interfaceʺ, ACS Applied Polymer Materials 6(4), 2054-2060, 2024 (DOI: 10.1021/acsapm.4c00109).

 

5)         Daniel J. Fesenmeier, Elliot S. Cooper, You-Yeon Won, ʺOvercoming Limitations of Conventional Solvent Exchange Methods: Achieving Monodisperse Non-Equilibrium Polymer Micelles through Equilibration-Nanoprecipitation (ENP)ʺ, Journal of Colloid and Interface Science 661, 861-869, 2024 (DOI: 10.1016/j.jcis.2024.01.167).

 

6)         Dhushyanth Viswanath, Jeehun Park, Vincenzo J. Pizzuti, Rahul Misra, Sung-Ho Shin, Junsang Doh, You-Yeon Won, ʺNanotechnology-Enhanced Radiotherapy and the Abscopal Effect: Current Status and Challenges of Nanomaterial-Based Radioimmunotherapyʺ, Wiley Interdisciplinary Reviews - Nanomedicine and Nanotechnology 16(1), e1924, 2024 (DOI: 10.1002/wnan.1924).

 

7)         Daniel J. Fesenmeier, Hyun Chang Kim, Seyoung Kim, You-Yeon Won, ʺDetermination of Block Copolymer Micelle Core Tg Using 1H NMR Transverse (T2) Relaxation Measurements of Micelle Coronasʺ, Macromolecules 56(22), 9156-9163, 2023 (DOI: 10.1021/acs.macromol.3c01486).

 

8)         Daniel J. Fesenmeier, Seyoung Kim, You-Yeon Won, ʺEffect of Temperature on the Air-Water Surface Mechanical Behavior of Water-Spread Block Copolymer Micellesʺ, Soft Matter 19, 9269-9281, 2023 (DOI: 10.1039/D3SM01003A).

 

9)         Seyoung Kim, Sungwan Park, Daniel J. Fesenmeier, You-Yeon Won, ʺExcipient-Free Lyophilization of Block Copolymer Micelles for Potential Lung Surfactant Therapy Applicationsʺ, International Journal of Pharmaceutics 646, 123476, 2023 (DOI: 10.1016/j.ijpharm.2023.123476).

 

10)      Seyoung Kim, Sungwan Park, Daniel J. Fesenmeier, Taesuk Jun, Kaustabh Sarkar, You-Yeon Won, ʺSurface Pressure-Area Mechanics of Water-Spread Block Copolymer Micelle Monolayers at the Air-Water Interface: Effect of Hydrophobic Block Chemistryʺ, Langmuir 39(38), 13546-13559, 2023 (DOI: 10.1021/acs.langmuir.3c01574).

 

11)      Dhushyanth Viswanath, Sung-Ho Shin, Jin Yoo, Sandra E. Torregrosa-Allen, Haley A. Harper, Heidi E. Cervantes, Bennett D. Elzey, You-Yeon Won, ʺRadiation-Induced Photodynamic Therapy Using Calcium Tungstate Nanoparticles and 5-Aminolevulinic Acid Prodrugʺ, Biomaterials Science 11, 6311-6324, 2023 (DOI: 10.1039/D3BM00921A).

 

12)      Seyoung Kim, Minhwan Lee, Hyun Chang Kim, YongJoo Kim, Won Bo Lee, You-Yeon Won, ʺDetermination of Glass Transition Temperatures in Bulk and Micellar Nanoconfined Polymers by Using Fluorescent Molecular Rotors as Probes for Changes in Free Volumeʺ, Macromolecules 56(16), 6290-6304, 2023 (DOI: 10.1021/acs.macromol.3c00968).

 

13)      Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxin Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, Qing Deng, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, ʺCAR-Neutrophil Mediated Delivery of Tumor-Microenvironment Responsive Nanodrugs for Glioblastoma Chemo-Immunotherapyʺ, Nature Communications 14, 2266, 2023 (DOI: 10.1038/s41467-023-37872-4).

 

14)      Daniel J. Fesenmeier, Madathilparambil V. Suresh, Seyoung Kim, Sungwan Park, Krishnan Raghavendran, You-Yeon Won, ʺPolymer Lung Surfactants Attenuate Direct Lung Injury in Miceʺ, ACS Biomaterials Science & Engineering 9(5), 2716-2730, 2023 (DOI: 10.1021/acsbiomaterials.3c00061).

 

15)      Dhushyanth Viswanath, You-Yeon Won, ʺCombining Radiotherapy (RT) and Photodynamic Therapy (PDT): Clinical Studies on Conventional RT-PDT Approaches and Novel Nanoparticle-Based RT-PDT Approaches under Preclinical Evaluationʺ, ACS Biomaterials Science & Engineering 8(9), 3644-3658, 2022 (DOI: 10.1021/acsbiomaterials.2c00287).

 

16)      Kaustabh Sarkar, Sandra E. Torregrosa-Allen, Bennett D. Elzey, Sanjeev Narayanan, Mark P. Langer, Gregory A. Durm, You-Yeon Won, ʺEffect of Paclitaxel Stereochemistry on X-ray-Triggered Release of Paclitaxel from CaWO4/Paclitaxel-Coloaded PEG-PLA Nanoparticlesʺ, Molecular Pharmaceutics 19(8), 2776-2794, 2022 (DOI: 10.1021/acs.molpharmaceut.2c00148). Correction: Molecular Pharmaceutics 20(8), 4331-4334, 2023 (DOI: 10.1021/acs.molpharmaceut.3c00510).

 

17)      Seyoung Kim, Daniel J. Fesenmeier, Sungwan Park, Sandra E. Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, ʺPulmonary Pharmacokinetics of Polymer Lung Surfactants Following Pharyngeal Administration in Miceʺ, Biomacromolecules 23(6), 2471-2484, 2022 (DOI: 10.1021/acs.biomac.2c00221).

 

18)      Daniel J. Fesenmeier, Sungwan Park, Seyoung Kim, You-Yeon Won, ʺSurface Mechanical Behavior of Water-Spread Poly(styrene)-Poly(ethylene glycol) (PS-PEG) Micelles at the Air-Water Interface: Effect of Micelle Size and Polymer End/Linking Group Chemistryʺ, Journal of Colloid and Interface Science 617, 764-777, 2022 (DOI: 10.1016/j.jcis.2022.03.008).

 

19)      Jin Yoo, Dhushyanth Viswanath, You-Yeon Won, ʺStrategy for Synthesis of Statistically Sequence-Controlled PEG-PLGA, and Effects of Sequence Distribution on Interaction and Drug Release Propertiesʺ, ACS Macro Letters 10, 1510-1516, 2021 (DOI: 10.1021/acsmacrolett.1c00637).

 

20)      Samruddhi Patil, Jin Yoo, You-Yeon Won, ʺInvestigation of the Mechanisms and Kinetics of DBU-Catalyzed PLGA Copolymerization via a Full-Scale Population Balance Analysisʺ, Industrial & Engineering Chemistry Research 60(41), 14865-14700, 2021 (DOI: 10.1021/acs.iecr.1c03096).

 

21)      Anish P. Patel, Christopher R. Schorr, Dhushyanth Viswanath, Kaustabh Sarkar, Natalie J. Streb, Vincenzo J. Pizzuti, Rahul Misra, Jaewon Lee, You-Yeon Won, ʺPilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG-PLA Block Copolymer-Encapsulated CaWO4 Radioluminescent Nanoparticles for Theranostic Applicationsʺ, Industrial & Engineering Chemistry Research 60(19), 7082-7096, 2021 (DOI: 10.1021/acs.iecr.0c05852).

 

22)      You-Yeon Won, Doraiswami Ramkrishna, ʺAddition to ʺRevised Formulation of Fickʹs, Fourierʹs, and Newtonʹs Laws for Spatially Varying Linear Transport Coefficientsʺʺ, ACS Omega 5(51), 33484-33487, 2020 (DOI: 10.1021/acsomega.0c02856).

 

23)      Jin Yoo, You-Yeon Won, ʺPhenomenology of the Initial Burst Release of Drugs from PLGA Microparticlesʺ, ACS Biomaterials Science & Engineering 6(11), 6053-6062, 2020 (DOI: 10.1021/acsbiomaterials.0c01228).

 

24)      Dong Woo Kim, Grigori A. Medvedev, James M. Caruthers, Jun Young Jo, You-Yeon Won, Jaewoo Kim, ʺEnhancement of Mechano-Sensitivity for Spiropyran-Linked Poly(dimethylsiloxane) via Solvent Swellingʺ, Macromolecules 53(18), 7954-7961, 2020 (DOI: 10.1021/acs.macromol.0c00985).

 

25)      Vincenzo J. Pizzuti, Dhushyanth Viswanath, Sandra E. Torregrosa-Allen, Melanie P. Currie, Bennett D. Elzey, You-Yeon Won, ʺBilirubin-Coated Radio-Luminescent Particles for Radiation-Induced Photodynamic Therapyʺ, ACS Applied Bio Materials 3(8), 4858-4872, 2020 (DOI: 10.1021/acsabm.0c00354).

 

26)      Jaewon Lee, Jingyi Pan, Jaehun Chun, You-Yeon Won, ʺUnexpected Conformational Behavior of Poly(poly(ethylene glycol) methacrylate)-Poly(propylene carbonate)-Poly(poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA) Amphiphilic Block Copolymers in Micellar Solution and at the Air-Water Interfaceʺ, Journal of Colloid and Interface Science 566, 304-315, 2020 (DOI: 10.1016/j.jcis.2020.01.080). Corrigendum: Journal of Colloid and Interface Science 586, 596, 2021 (DOI: 10.1016/j.jcis.2020.10.126).

 

27)      Vincenzo J. Pizzuti, Rahul Misra, Jaewon Lee, Sandra E. Torregrosa-Allen, Melanie P. Currie, Scott R. Clark, Anish P. Patel, Christopher R. Schorr, Yava Jones-Hall, Michael O. Childress, Jeannie M. Plantenga, Nicholas J. Rancilio, Bennett D. Elzey, You-Yeon Won, ʺFolic Acid-Conjugated Radioluminescent Calcium Tungstate Nanoparticles as Radio-Sensitizers for Cancer Radiotherapyʺ, ACS Biomaterials Science & Engineering 5(9), 4776-4789, 2019 (DOI: 10.1021/acsbiomaterials.9b00773).

 

28)      You-Yeon Won, Doraiswami Ramkrishna, ʺRevised Formulation of Fickʹs, Fourierʹs, and Newtonʹs Laws for Spatially Varying Linear Transport Coefficientsʺ, ACS Omega 4(6), 11215-11222, 2019 (DOI: 10.1021/acsomega.9b00736).

 

29)      Rahul Misra, Kaustabh Sarkar, Jaewon Lee, Vincenzo J. Pizzuti, Deborah S. Lee, Melanie P. Currie, Sandra E. Torregrosa-Allen, David E. Long, Gregory A. Durm, Mark P. Langer, Bennett D. Elzey, You-Yeon Won, ʺRadioluminescent Nanoparticles for Radiation-Controlled Release of Drugsʺ, Journal of Controlled Release 303, 237-252, 2019 (DOI: 10.1016/j.jconrel.2019.04.033). Corrigendum: Journal of Controlled Release 356, 130, 2023 (DOI: 10.1016/j.jcis.2023.02.033).

 

30)      Byoungjin Chun, Jin Seok Park, Hyun Wook Jung, You-Yeon Won, ʺShear-Induced Particle Migration and Segregation in Non-Brownian Bidisperse Suspensions under Planar Poiseuille Flowʺ, Journal of Rheology 63(3), 437-453, 2019 (DOI: 10.1122/1.5065406).

 

31)      Hyun Chang Kim, Madathilparambil V. Suresh, Vikas V. Singh, Davis Q. Arick, David A. Machado-Aranda, Krishnan Raghavendran, You-Yeon Won, ʺPolymer Lung Surfactantsʺ, ACS Applied Bio Materials 1(3), 581-592, 2018 (DOI: 10.1021/acsabm.8b00061).

 

32)      Jaewon Lee, Sung Duk Jo, Haejun Chung, Wooram Um, Rohith Chandrasekar, Yun Hwa Choi, Vladmir M. Shalaev, You-Yeon Won, ʺLaser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancementʺ, ACS Applied Materials & Interfaces 10(31), 26084-26098, 2018 (DOI: 10.1021/acsami.8b09630).

 

33)      Hyun Chang Kim, Davis Q. Arick, You-Yeon Won, ʺAir-Water Interfacial Properties of Chloroform-Spread versus Water-Spread Poly((D,L-lactic acid-co-glycolic acid)-block-ethylene glycol) (PLGA-PEG) Polymersʺ, Langmuir 34(16), 4874-4887, 2018 (DOI: 10.1021/acs.langmuir.8b00566).

 

34)      Hyun Chang Kim, You-Yeon Won, ʺClinical, Technological, and Economic Issues Associated with Developing New Lung Surfactant Therapeuticsʺ, Biotechnology Advances 36(4), 1185-1193, 2018 (DOI: 10.​1016/​j.​biotechadv.​2018.​03.​017).

 

35)      Sung Duk Jo, Jaewon Lee, Min Kyung Joo, Vincenzo J. Pizzuti, Nicholas J. Sherck, Slgi Choi, Beom Suk Lee, Sung Ho Yeom, Sang Yoon Kim, Sun Hwa Kim, Ick Chan Kwon, You-Yeon Won, ʺPEG-PLA-Coated and Uncoated Radio-Luminescent CaWO4 Micro- and Nanoparticles for Concomitant Radiation and UV-A/Radio-Enhancement Cancer Treatmentsʺ, ACS Biomaterials Science & Engineering 4(4), 1445-1462, 2018 (DOI: 10.1021/acsbiomaterials.8b00119).

 

36)      Scott R. Clark, Keel Yong Lee, Hoyoung Lee, Jawahar Khetan, Hyun Chang Kim, Yun Hwa Choi, Kwanwoo Shin, You-Yeon Won, ʺDetermining the Effects of PEI Adsorption on the Permeability of 1,2-Dipalmitoylphosphatidylcholine/Bis(monoacylglycero)phosphate Membranes under Osmotic Stressʺ, Acta Biomaterialia 65, 317-326, 2018 (DOI: 10.1016/j.actbio.2017.10.027).

 

37)      Nicholas J. Sherck, You-Yeon Won, ʺA Simulation Study on the Feasibility of Radiotherapy Dose Enhancement with Calcium Tungstate and Hafnium Oxide Nano- and Microparticlesʺ, Medical Physics 44(12), 6583-6588, 2017 (DOI: 10.1002/mp.12588). An earlier and longer version of this article (titled ʺA Simulation Study on the Feasibility of Radio Enhancement Therapy with Calcium Tungstate and Hafnium Oxide Nanoparticlesʺ) has been published in arXiv (http://arxiv.org/abs/1608.05302).

 

38)      Seong-Eun Kim, Bo-Ram Lee, Hohyeon Lee, Sung Duk Jo, Hyuncheol Kim, You-Yeon Won, Jeewon Lee, ʺNear-Infrared Plasmonic Assemblies of Gold Nanoparticles with Multimodal Functions for Targeted Cancer Theragnosisʺ, Scientific Reports 7, 17327, 2017 (DOI:10.1038/s41598-017-17714-2).

 

39)      Hyun Chang Kim, Yun Hwa Choi, Wei Bu, Mati Meron, Binhua Lin, You-Yeon Won, ʺIncreased Humidity Can Soften Glassy Langmuir Polymer Films by Two Mechanisms: Plasticization of the Polymer Material, and Suppression of the Evaporation Cooling Effectʺ, Physical Chemistry Chemical Physics 19, 10663-10675, 2017 (DOI: 10.1039/C7CP00785J).

 

40)      Seong-Eun Kim, Sun Duk Jo, Koo Chul Kwon, You-Yeon Won, Jeewon Lee, ʺGenetic Assembly of Double-Layered Fluorescent Protein Nanoparticles for Cancer Targeting and Imagingʺ, Advanced Science 1600471, 2017 (DOI: 10.1002/advs.201600471).

 

41)      Jaewon Lee, Seulgi Choi, Ki Hyun Kim, Hock Gan Heng, Sandra E. Torregrosa-Allen, Benjamin S. Ramsey, Bennett D. Elzey, You-Yeon Won, ʺNon-Toxic Formulations of Scintillation Nanocrystals for Use as X-Ray Computed Tomography (CT) Contrast Agentsʺ, Bioconjugate Chemistry 28(1), 171-182, 2017 (DOI: 10.1021/acs.bioconjchem.6b00451).

 

42)      Nicholas J. Sherck, Hyun Chang Kim, You-Yeon Won, ʺElucidating a Unified Mechanistic Scheme for the DBU-Catalyzed Ring-Opening Polymerization of Lactide to Poly(lactic acid), PLAʺ, Macromolecules 49(13), 4699-4713, 2016 (DOI: 10.1021/acs.macromol.6b00621).

 

43)      Sung Duk Jo, Sook Hee Ku, You-Yeon Won, Sun Hwa Kim, Ick Chan Kwon, ʺTargeted Nanotheranostics for Future Personalized Medicine: Recent Progress in Cancer Therapyʺ, Theranostics 6(9), 1362-1377, 2016 (DOI: 10.7150/thno.15335).

 

44)      Jaewon Lee, Nicholas J. Rancilio, Jean M. Poulson, You-Yeon Won, ʺBlock Copolymer-Encapsulated CaWO4 Nanoparticles: Synthesis, Formulation, and Characterizationʺ, ACS Applied Materials & Interfaces 8(13), 8608-8619, 2016 (DOI: 10.1021/acsami.6b00727).

 

45)      Hyun Chang Kim, Hoyoung Lee, Jawahar Khetan, You-Yeon Won, ʺSurface Mechanical and Rheological Behaviors of Biocompatible Poly((D,L-lactic acid-ran-glycolic acid)-block-ethylene glycol) (PLGA-PEG) and Poly((D,L-lactic acid-ran-glycolic acid-ran-ε-caprolactone)-block-ethylene glycol) (PLGACL-PEG) Block Copolymers at the Air-Water Interfaceʺ, Langmuir 31(51), 13821-13833, 2015 (DOI: 10.1021/acs.langmuir.5b03622).

 

46)      Davis Q. Arick, Yun Hwa Choi, Hyun Chang Kim, You-Yeon Won, ʺEffects of Nanoparticles on the Mechanical Functioning of the Lungʺ, Advances in Colloid and Interface Science 225, 218-228, 2015 (DOI: 10.1016/j.cis.2015.10.002).

 

47)      Hoyoung Lee, Jaewon Lee, Jaeyoung Park, Taewook Kwon, Seunggweon Hong, You-Yeon Won, ʺCO2-Producing Polymer Micellesʺ, Polymer Degradation and Stability 120, 149-157, 2015 (DOI: 10.1016/j.polymdegradstab.2015.07.002).

 

48)      Hyun Chang Kim, Hoyoung Lee, Hyunjung Jung, Yun Hwa Choi, Mati Meron, Binhua Lin, Joona Bang, You-Yeon Won, ʺHumidity-Dependent Compression-Induced Glass Transition of the Air-Water Interfacial Langmuir Films of Poly(D,L-lactic acid-ran-glycolic acid) (PLGA)ʺ, Soft Matter 11, 5666-5677, 2015 (DOI: 10.1039/C4SM02535K).

 

49)      Hyungsu Kim, Jaegeun Lee, You-Yeon Won, ʺA Simple Derivation of the Critical Condition for the Ultrasonic Atomization of Polymer Solutionsʺ Ultrasonics 61, 20-24, 2015 (DOI: 10.1016/j.ultras.2015.04.007).

 

50)      Vasilios Tsouris, Min Kyung Joo, Sun Hwa Kim, Ick Chan Kwon, You-Yeon Won, ʺNano Carriers That Enable Co-Delivery of Chemotherapy and RNAi Agents for Treatment of Drug-Resistant Cancersʺ, Biotechnology Advances 32(5), 1037-1050, 2014 (DOI: 10.1016/j.biotechadv.2014.05.006).

 

51)      Hoyoung Lee, Vasilios Tsouris, Yunho Lim, Rafid Mustafa, Je Choi, Yun Hwa Choi, Hae-Woong Park, Mati Meron, Binhua Lin, You-Yeon Won, ʺMacroscopic Lateral Heterogeneity Observed in a Laterally-Mobile Immiscible Mixed Polyelectrolyte/Neutral Polymer Brushʺ, Soft Matter 10, 3771-3782, 2014 (DOI: 10.1039/C4SM00022F).

 

52)      Hoyoung Lee, Yeji Kim, Patrick G. Schweickert, Stephen F. Konieczny, You-Yeon Won, ʺA Photo-Degradable Gene Delivery System for Enhanced Nuclear Gene Transcriptionʺ, Biomaterials 35(3), 1040-1049, 2014 (DOI:10.1016/j.biomaterials.2013.10.030).

 

53)      You-Yeon Won, Hoyoung Lee, ʺʺpH Phoresisʺ: A New Concept That Can Be Used for Improving Drug Delivery to Cancer Cellsʺ, Journal of Controlled Release 170(3), 396-400, 2013 (DOI: 10.1016/j.jconrel.2013.06.016). See ʺNanoparticles, ʹpH phoresisʹ could improve cancer drug deliveryʺ in Purdue News (July 8, 2013).

 

54)      Dana J. Gary, Jungbin Min, Youngwook Kim, Keunchil Park, You-Yeon Won, ʺThe Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly(2-(dimethylamino)ethyl methacrylate)-Based siRNA Complexesʺ, Macromolecular Bioscience 13(8), 1059-1071, 2013 (DOI: 10.1002/mabi.201300046).

 

55)      Hae-Woong Park, Je Choi, Kimberly Ohn, Hyunsuk Lee, Jin Woong Kim, You-Yeon Won, ʺStudy of the Air-Water Interfacial Properties of Biodegradable Polyesters and Their Block Copolymers with Poly(ethylene glycol)ʺ, Langmuir 28(31), 11555-11566, 2012 (DOI: 10.1021/la300810q).

 

56)      Hoyoung Lee, Dae Hwan Kim, Kevin N. Witte, Kimberly Ohn, Je Choi, Bulent Akgun, Sushil Satija, You-Yeon Won, ʺWater is a Poor Solvent for Densely Grafted Poly(ethylene oxide) Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis of Neutron Reflectivity and Surface Pressure-Area Isotherm Dataʺ, Journal of Physical Chemistry B 116(24), 7367-7378, 2012 (DOI: 10.1021/jp301817e).

 

57)      Hoyoung Lee, Dae Hwan Kim, Hae-Woong Park, Nathan A. Mahynski, Kyungil Kim, Mati Meron, Binhua Lin, You-Yeon Won, ʺReduced Water Density in a Poly(ethylene oxide) Brushʺ, Journal of Physical Chemistry Letters 3, 1589-1595, 2012 (DOI: 10.1021/jz3002772).

 

58)      Dae Hwan Kim, Alexander Wei, You-Yeon Won, ʺPreparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ, ACS Applied Materials & Interfaces 4(4), 1872-1877, 2012 (DOI: 10.1021/am300198v).

 

59)      Rikkert J. Nap, You-Yeon Won, Igal Szleifer, ʺConfinement Induced Lateral Segregation of Polymer Coated Nanospheresʺ, Soft Matter 8(5), 1688-1700, 2012 (DOI: 10.1039/c2sm06549e).

 

60)      Dae Hwan Kim, You-Yeon Won, ʺIn Situ-Polymerized Carbon Nanotube/Polyimide Nanocomposites: Effect of Reaction Stoichiometry on the Glass Transition Properties of the Nanocompositesʺ, Macromolecular Reaction Engineering 6(1), 45-56, 2012 (DOI: 10.1002/mren.201100027). This article has been highlighted on the front cover of the journal.

 

61)      Dana J. Gary, Hoyoung Lee, Rahul Sharma, Jae-Sung Lee, Youngwook Kim, Zheng Yun Cui, Di Jia, Valorie D. Bowman, Paul R. Chipman, Lei Wan, Yi Zou, Guangzhao Mao, Keunchil Park, Brittney-Shea Herbert, Stephen F. Konieczny, You-Yeon Won, ʺInfluence of Nano-Carrier Architecture on In Vitro siRNA Delivery Performance and In Vivo Biodistribution: Polyplexes vs. Micelleplexesʺ, ACS Nano 5(5), 3493-3505, 2011 (DOI: 10.1021/nn102540y).

 

62)      Hoyoung Lee, Sang Ha Son, Rahul Sharma, You-Yeon Won, ʺA Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))ʺ, Journal of Physical Chemistry B 115(5), 844-860, 2011 (DOI: 10.1021/jp109151s).

 

63)      Umesh S. Kestur, Hoyoung Lee, Darlene Santiago, Carlos Rinaldi, You-Yeon Won, Lynne S. Taylor, ʺEffects of the Molecular Weight and Concentration of Polymer Additives, and Temperature on the Melt Crystallization Kinetics of a Small Drug Moleculeʺ, Crystal Growth & Design 10(8), 3585-3595, 2010 (DOI: 10.1021/cg1004853).

 

64)      Jaehyun Hur, Nathan A. Mahynski, You-Yeon Won, ʺCrystallization of Bidisperse Repulsive Colloids in Two-Dimensional Space: A Study of Model Systems Constructed at the Air-Water Interfaceʺ, Langmuir 26(14), 11737-11749, 2010 (DOI: 10.1021/la101313r).

 

65)      Kevin N. Witte, Sumit Kewalramani, Ivan Kuzmenko, Wei Sun, Masafumi Fukuto, You-Yeon Won, ʺFormation and Collapse of Single-Monomer-Thick Monolayers of Poly(n-Butyl Acrylate) at the Air-Water Interfaceʺ, Macromolecules 43(6), 2990-3003, 2010 (DOI: 10.1021/ma901842q).

 

66)      Jaehyun Hur, Kevin N. Witte, Wei Sun, You-Yeon Won, ʺOn the Origins of the Salt-Concentration-Dependent Instability and Lateral Nanoscale Heterogeneities of Weak Polyelectrolyte Brushes: Gradient Brush Experiment, and Flory-Type Theoretical Analysisʺ, Langmuir 26(3), 2021-2034, 2010 (DOI: 10.1021/la902549b).

 

67)      You-Yeon Won, Rahul Sharma, Stephen F. Konieczny, ʺMissing Pieces in Understanding the Intracellular Trafficking of Polycation/DNA Complexesʺ, Journal of Controlled Release 139(2), 88-93, 2009 (DOI: 10.1016/j.jconrel.2009.06.031). Erratum: Journal of Controlled Release 152(2), 326, 2009 (DOI: 10.1016/j.jconrel.2011.04.003).

 

68)      Kevin N. Witte, Sangtae Kim, You-Yeon Won, ʺSelf-Consistent Field Theory Study of the Effect of Grafting Density on the Height of a Weak Polyelectrolyte Brushʺ, Journal of Physical Chemistry B 113(32), 11076-11084, 2009 (DOI: 10.1021/jp809814j).

 

69)      Kevin N. Witte, Jaehyun Hur, Wei Sun, Sangtae Kim, You-Yeon Won, ʺEvidence of Lateral Nanoscale Heterogeneities in Weak Polyelectrolyte Brushesʺ, Macromolecules 41(23), 8960-8963, 2008 (DOI: 10.1021/ma801412u).

 

70)      Rahul Sharma, Jae-Sung Lee, Ryan C. Bettencourt, Chuan Xiao, Stephen F. Konieczny, You-Yeon Won, ʺEffects of the Incorporation of a Hydrophobic Middle Block into a PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction Properties of the Polymer-DNA Complexesʺ, Biomacromolecules 9(11), 3294-3307, 2008 (DOI: 10.1021/bm800876v).

 

71)      Jaehyun Hur, You-Yeon Won, ʺFabrication of High-Quality Non-Close-Packed 2D Colloid Crystals by Template-Guided Langmuir-Blodgett (LB) Particle Depositionʺ, Soft Matter 4(6), 1261-1269, 2008 (DOI: 10.1039/b716218a). See ʺSelf-assembling Method Could Lead to Inexpensive Diamond-like Crystals for Technologyʺ in ScienceDaily (April 22, 2008). This article was one of the ten most downloaded Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp)

 

72)      Jaehyun Hur, You-Yeon Won, ʺTwo-Dimensional Colloid Crystals Templated by Polyelectrolyte Multilayer Patternsʺ, Langmuir 24(10), 5382-5392, 2008 (DOI: 10.1021/la704050t).

 

73)      Kevin N. Witte, You-Yeon Won, ʺEffect of Interfacial Curvature on Mixed Polyelectrolyte and Neutral Polymer Brushes: An SCF Numerical Analysisʺ, Macromolecules 41(7), 2735-2738, 2008 (DOI: 10.1021/ma071682e).

 

74)      Yinyan Zhao, M. Teresa Carvajal, You-Yeon Won, Michael T. Harris, ʺPreparation of Calcium Alginate Microgel Beads by an Electrodispersion Reactor Using an Internal Source of Calcium Carbonate Nanoparticlesʺ, Langmuir 23(25), 12489-12496, 2007 (DOI: 10.1021/la701795y).

 

75)      Donghui Zhu, Mark A. Haidekker, Jae-Sung Lee, You-Yeon Won, James C.-M. Lee, ʺApplication of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Meltsʺ, Macromolecules 40(21), 7730-7732, 2007 (DOI: 10.1021/ma0702288).

 

76)      Dana J. Gary, Nitin Puri, You-Yeon Won, ʺPolymer-Based siRNA Delivery: Perspectives on the Fundamental and Phenomenological Distinctions from Polymer-Based DNA Deliveryʺ, Journal of Controlled Release 121(1-2), 64-73, 2007 (DOI: 10.1016/j.jconrel.2007.05.021).

 

77)      Kevin N. Witte, You-Yeon Won, ʺSelf-Consistent-Field Analysis of Mixed Polyelectrolyte and Neutral Polymer Brushesʺ, Macromolecules 39(22), 7757-7768, 2006 (DOI: 10.1021/ma0608370).

 

78)      Rahul Sharma, Ayush Goyal, James M. Caruthers, You-Yeon Won, ʺInhibitive Chain Transfer to Ligand in the ATRP of n-Butyl Acrylateʺ, Macromolecules 39(14), 4680-4689, 2006 (DOI: 10.1021/ma060374y).

 

79)      You-Yeon Won, Steve P. Meeker, Veronique Trappe, David A. Weitz, Nancy Z. Diggs, Jacob I. Emert, ʺEffect of Temperature on Carbon Black Agglomeration in Hydrocarbon Liquid with Adsorbed Dispersantʺ, Langmuir 21(4), 924-932, 2005 (DOI: 10.1021/la047906t).

 

80)      Patrick E. Trapa, You-Yeon Won, Simon C. Mui, Elsa A. Olivetti, Biying Huang, Donald R. Sadoway, Anne M. Mayes, Steven Dallek, ʺRubbery Graft Copolymer Electrolytes for Solid-State, Thin-Film Lithium Batteriesʺ, Journal of the Electrochemical Society 152(1), A1-A5, 2005 (DOI: 10.1149/1.1824032).

 

81)      You-Yeon Won, ʺImaging Nanostructured Fluids Using Cryo-TEMʺ, Korean Journal of Chemical Engineering 21(1), 296-302, 2004 (DOI: 10.1007/BF02705412). This article has been referenced in an STTR call from the US Army, titled ʺNanoscale In-Solution TEM Sample Stage with Manipulation Capability (A08-T029)ʺ (January 22, 2008).

 

82)      You-Yeon Won, H. Ted Davis, Frank S. Bates, ʺMolecular Exchange in PEO-PB Micelles in Waterʺ, Macromolecules 36(3), 953-955, 2003 (DOI: 10.1021/ma021439+).

 

83)      Maria M. Santore, Dennis E. Discher, You-Yeon Won, Frank S. Bates, Daniel A. Hammer, ʺEffect of Surfactant on Unilamellar Polymeric Vesicles: Altered Membrane Properties and Stability in the Limit of Weak Surfactant Partitioningʺ, Langmuir 18(20), 7299-7308, 2002 (DOI: 10.1021/la0201319).

 

84)      Jonathan F. Hester, Pallab Banergee, You-Yeon Won, Ariya Akthakul, Metin H. Acar, Anne M. Mayes, ʺATRP of Amphiphilic Graft Copolymers Based on PVDF and Their Use as Membrane Additivesʺ, Macromolecules 35(20), 7652-7661, 2002 (DOI: 10.1021/ma0122270).

 

85)      Patrick E. Trapa, Biying Huang, You-Yeon Won, Donald R. Sadoway, Anne M. Mayes, ʺBlock Copolymer Electrolytes Synthesized by Atom Transfer Radical Polymerization for Solid-State, Thin-Film Lithium Batteriesʺ, Electrochemical and Solid-State Letters 5(5), A85-A88, 2002 (DOI: 10.1149/1.1461996).

 

86)      You-Yeon Won, Aaron K. Brannan, H. Ted Davis, Frank S. Bates, ʺCryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and Vesicles Formed in Water by Poly(ethylene oxide)-based Block Copolymersʺ, Journal of Physical Chemistry B 106(13), 3354-3364, 2002 (DOI: 10.1021/jp013639d).

 

87)      Bohdana M. Discher, Harry Bermudez, Daniel A. Hammer, Dennis E. Discher, You-Yeon Won, Frank S. Bates, ʺCrosslinked Polymersome Membranes: Vesicles with Broadly Adjustable Stabilityʺ, Journal of Physical Chemistry B 106(11), 2848-2854, 2002 (DOI: 10.1021/jp011958z).

 

88)      You-Yeon Won, Kristofer Paso, H. Ted Davis, Frank S. Bates, ʺComparison of Original and Cross-linked Wormlike Micelles of Poly(ethylene oxide-b-butadiene) in Water: Rheological Properties and Effects of Poly(ethylene oxide) Additionʺ, Journal of Physical Chemistry B 105(35), 8302-8311, 2001 (DOI: 10.1021/jp004078d).

 

89)      James C.-M. Lee, Harry Bermudez, Bohdana M. Discher, Maureen A. Sheehan, You-Yeon Won, Frank S. Bates, Dennis E. Discher, ʺPreparation, Stability, and In Vitro Performance of Vesicles Made from Diblock Copolymersʺ, Biotechnology and Bioengineering 73(2), 135-145, 2001 (DOI: 10.1002/bit.1045).

 

90)      Byeongmoon Jeong, Merinda R. Kibbey, Jerome C. Birnbaum, You-Yeon Won, Anna Gutowska, ʺThermogelling Biodegradable Polymers with Hydrophilic Backbones: PEG-g-PLGAʺ, Macromolecules 33(22), 8317-8322, 2000 (DOI: 10.1021/ma000638v).

 

91)      You-Yeon Won, H. Ted Davis, Frank S. Bates, Michael Agamalian, George D. Wignall, ʺSegment Distribution of the Micellar Brushes of Poly(ethylene oxide) via Small-Angle Neutron Scatteringʺ, Journal of Physical Chemistry B 104(30), 7134-7143, 2000 (DOI: 10.1021/jp000457v). Addition/Correction: Journal of Physical Chemistry B 104(38), 9054-9054, 2000 (DOI: 10.1021/jp002934f).

 

92)      Yi Zheng, You-Yeon Won, Frank S. Bates, H. Ted Davis, L. E. (Skip) Scriven, Yeshayahu (Ishi) Talmon, ʺDirectly Resolved Core-Corona Structure of Block Copolymer Micelles by Cryo-Transmission Electron Microscopyʺ, Journal of Physical Chemistry B 103(47), 10331-10334, 1999 (DOI: 10.1021/jp9923264).

 

93)      Bohdana M. Discher, You-Yeon Won, David S. Ege, James C.-M. Lee, Frank S. Bates, Dennis E. Discher, Daniel A. Hammer, ʺPolymersomes: Vesicles Made from Diblock Copolymersʺ, Science 284 (5417), 1143-1146, 1999 (DOI: 10.1126/science.284.5417.1143).

 

94)      You-Yeon Won, H. Ted Davis, Frank S. Bates, ʺGiant Wormlike Rubber Micellesʺ, Science 283 (5404), 960-963, 1999 (DOI: 10.1126/science.283.5404.960).

 

 

BOOK CHAPTERS

 

95)      You-Yeon Won, Frank S. Bates, ʺNonionic Block Copolymer Wormlike Micellesʺ, in Giant Micelles: Properties and Applications (Editors: R. Zana, E. W. Kaler), CRC Press/Taylor & Francis, Boca Raton, FL, 2007.

 

 

PUBLISHED PATENTS

 

96)      (a) ʺRadioluminescent Nanoparticles for Radiation-Triggered Controlled Release Drugsʺ You-Yeon Won, Rahul Misra, Jaewon Lee, pending U.S. Provisional Patent, Application No. 62/556,289, PRF Reference No. 68028-01, filed on September 8, 2017. (b) ʺRadioluminescent Nanoparticles for Radiation-Triggered Controlled Release Drugsʺ You-Yeon Won, Rahul Misra, Jaewon Lee, Kaustabh Sarkar, Vincenzo J. Pizzuti, pending PCT/U.S. Patent, Application No. 18/49823, PRF Reference No. 68028-02, filed on September 7, 2018.

 

97)      (a) ʺPolymer Lung Surfactantsʺ You-Yeon Won, Hyun Chang Kim, pending U.S. Provisional Patent, Application No. 62/374,325, PRF Reference No. 67605-01, filed on August 12, 2016. (b) ʺPolymer Lung Surfactantsʺ You-Yeon Won, Hyung Chang Kim, pending PCT/U.S. Patent, Application No. 17/46426, PRF Reference No. 67605-02, filed on August 11, 2017. (c) ʺPolymer Lung Surfactantsʺ You-Yeon Won, Hyun Chang Kim, pending U.S. Continuation-in-Part Patent, Application No. 15881723, PRF Reference No. 67605-03, filed on January 26, 2018.

 

98)      (a) ʺRadio-Luminescent Particles for Enhancement of Radiation Cancer Therapyʺ, You-Yeon Won, Min Kyung Joo, Beom Suk Lee, Sang Yoon Kim, pending U.S. Provisional Patent, Application No. 62/101,275, PRF Reference No. 78695.P1.US, filed on January 8, 2015. (b) ʺRadio-Luminescent Particles for Enhancement of Radiation Cancer Therapyʺ, You-Yeon Won, Jaewon Lee, Sung Du Jo, Min Kyung Joo, Beom Suk Lee, Sang Yoon Kim, Sun Hwa Kim, pending PCT/U.S. Patent, Application No. 16/12616, PRF Reference No. 67028-03, filed on January 8, 2016. (c) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ You-Yeon Won, Jaewon Lee, pending PCT/U.S. Patent, Application No. 16/12684, PRF Reference No. 67028-02, filed on January 8, 2016. (d) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ You-Yeon Won, Jaewon Lee, nationalized in the U.S. on July 8, 2017 (PRF Reference No. 67028-04). (e) ʺNon-Toxic Formulations of Radio-Luminescent Nanoparticles for Use as Cancer Radio-Sensitizing Agentsʺ You-Yeon Won, Jaewon Lee, nationalized in the E.U. on August 8, 2017 (PRF Reference No. 67028-05).

 

99)      (a) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, You-Yeon Won, Hoyoung Lee, Jaewon Lee, Jaeyoung Park, Seunggweon Hong, pending U.S. Provisional Patent, Application No. 62/078,738, PRF Reference No. 78595.P1.US, filed on November 12, 2014. (b) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, You-Yeon Won, Hoyoung Lee, Jaewon Lee, Jaeyoung Park, Seunggweon Hong, pending PCT/U.S. Patent, Application No. 15/60430, PRF Reference No. 66901-02, filed on November 12, 2015. (c) ʺPoly(alkylene carbonate)-Based Amphiphilic Block Copolymers and Methods of Use Thereofʺ, You-Yeon Won, Hoyoung Lee, Jaewon Lee, Jaeyoung Park, Seunggweon Hong, nationalized in the U.S. on May 12, 2017 (PRF Reference No. 66901-03).

 

100)  (a) ʺPreparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micellesʺ, You-Yeon Won, Dae Hwan Kim, pending U.S. Provisional Patent, Application No. 61/619,548, PRF Reference No. 66166.P1.US, filed on April 3, 2012. (b) ʺBlock Copolymer (BCP) Encapsulated Nanoparticles and Methods of Use Thereofʺ, You-Yeon Won, Dae Hwan Kim, Ronald P. Andres, pending U.S. Patent, Application No. 13/837,705, PRF Reference No. 66166-02, filed on March 15, 2013, granted on October 10, 2017.

 

101)  ʺCross-linked Polymersomes and Related Encapsulating Membranesʺ, Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C.-M. Lee, Frank S. Bates, Daniel A. Hammer, U.S. Patent No. 7,867,512, filed on February 20, 2007, granted on January 11, 2011.

 

102)  ʺPolymersomes and Related Encapsulating Membranesʺ, Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C.-M. Lee, Frank S. Bates, Daniel A. Hammer, U.S. Patent No. 7,217,427 B2, filed on July 1, 2004, granted on May 15, 2007.

 

103)  ʺPolymersomes and Related Encapsulating Membranesʺ, Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C.-M. Lee, Frank S. Bates, Daniel A. Hammer, U.S. Patent No. 6,835,394, filed December 14, 1999, granted on December 28, 2004.