Our research currently focuses on: (1) development of polymer-based
drug/gene delivery and imaging agents, (2) understanding of the complex
behavior of charged polymers (“polyelectrolytes”), (3) investigations on
interfacial phenomena of polymers (with emphasis on polymer/polyelectrolyte
brushes, and Langmuir monolayers of polymers), and (4) fabrication
of complex functional structures by self-assembly of
colloids and block copolymers. Last updated on June 30, 2014.
1)
H. Kim, J. Lee, Y.-Y.
Won, “A Simple Derivation of the Critical Condition for the Ultrasonic
Atomization of Polymer Solutions”, submitted, 2014.
2)
H. Lee, P. G.
Schweickert, S. F. Konieczny, Y.-Y. Won, “RNAi-Assisted Gene Delivery”,
submitted, 2014.
3)
V. Tsouris, M. K.
Joo, S. H. Kim, I. C. Kwon, Y.-Y. Won, “Nano Carriers That Enable Co-Delivery
of Chemotherapy and RNAi Agents for Treatment of Drug-Resistant Cancers”, Biotechnology Advances in press, 2014 (DOI:
4)
H. Lee, V. Tsouris,
Y. Lim, R. Mustafa, J. Choi, Y. H. Choi, H.-W. Park, M. Meron, B. Lin, Y.-Y.
Won, “Macroscopic Lateral Heterogeneity Observed in a Laterally-Mobile
Immiscible Mixed Polyelectrolyte/Neutral Polymer Brush”, Soft Matter 10, 3771-3782, 2014 (DOI: 10.1039/C4SM00022F).
5)
H. Lee, Y. Kim, P. G.
Schweickert, S. F. Konieczny, Y.-Y. Won, “A Photo-Degradable Gene Delivery
System for Enhanced Nuclear Gene Transcription”, Biomaterials 35(3), 1040-1049, 2014 (DOI:
6)
Y.-Y. Won, H. Lee,
““pH Phoresis”: A New Concept That Can Be Used for Improving Drug Delivery to
Cancer Cells”, Journal of Controlled
Release 170(3), 396-400, 2013 (DOI: 10.1016/j.jconrel.2013.06.016). See "Nanoparticles,
'pH phoresis' could improve cancer drug delivery" in Purdue
News (July 8, 2013).
7)
D. J. Gary, J. Min, Y. Kim, K. Park, Y.-Y. Won, “The Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly(2-(dimethylamino)ethyl
methacrylate)-Based siRNA Complexes”, Macromolecular
Bioscience 13(8), 1059-1071, 2013 (DOI: 10.1002/mabi.201300046).
8)
H. W. Park, J. Choi,
K. Ohn, H. Lee, J. W. Kim, Y.-Y. Won, “Study of the Air-Water Interfacial
Properties of Biodegradable Polyesters and Their Block Copolymers with
Poly(ethylene glycol)”, Langmuir 28(31),
11555-11566, 2012 (DOI: 10.1021/la300810q).
9)
H. Lee, D. H. Kim, K. N. Witte, K. Ohn, J.
Choi, B. Akgun, S. Satija, Y.-Y. Won, “Water
is a Poor Solvent for Densely Grafted Poly(ethylene oxide) Chains: A Conclusion Drawn from a Self-Consistent Field Theory-Based Analysis of
Neutron Reflectivity and Surface Pressure-Area Isotherm Data”, Journal of Physical Chemistry B 116(24),
7367-7378, 2012 (DOI: 10.1021/jp301817e).
10)
H. Lee, D. H. Kim, H.-W. Park, N. A.
Mahynski, K. Kim, M. Meron, B. Lin, Y.-Y. Won, “Reduced Water Density in a
Poly(ethylene oxide) Brush”, Journal of
Physical Chemistry Letters 3, 1589-1595,
2012 (DOI: 10.1021/jz3002772).
11)
D. H. Kim, A. Wei, Y.-Y.
Won, “Preparation of Super-Stable Gold Nanorods via Encapsulation into Block
Copolymer Micelles”, ACS Applied
Materials & Interfaces 4(4),
1872-1877, 2012 (DOI: 10.1021/am300198v).
12)
R. Nap, Y.-Y. Won, I.
Szleifer, “Confinement Induced Lateral Segregation of Polymer Coated
Nanospheres”, Soft Matter
8(5), 1688-1700, 2012 (DOI: 10.1039/c2sm06549e).
13)
D. H. Kim, Y.-Y. Won,
“In Situ-Polymerized Carbon Nanotube/Polyimide Nanocomposites: Effect of
Reaction Stoichiometry on the Glass Transition Properties of the
Nanocomposites”, Macromolecular Reaction
Engineering 6(1), 45-56, 2012 (DOI: 10.1002/mren.201100027). This article has been highlighted on the front cover
of the journal.
14)
D. J. Gary, H. Lee, R. Sharma, J.-S. Lee,
Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman,
L. Wan, Y. Zou, G. Mao, K. Park, B.-S.
Herbert, S. F. Konieczny, Y.-Y. Won, “Influence of Nano-Carrier
Architecture on In Vitro siRNA Delivery Performance and In Vivo
Biodistribution: Polyplexes vs. Micelleplexes”, ACS Nano 5(5),
3493-3505, 2011 (DOI: 10.1021/nn102540y).
15)
H. Lee, S. H. Son, R.
Sharma, Y.-Y. Won, “A Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl
methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))”, Journal of Physical Chemistry B 115(5),
844-860, 2011 (DOI: 10.1021/jp109151s).
16)
U. S. Kestur, H. Lee,
D. Santiago, C. Rinaldi, Y.-Y. Won, L. S. Taylor, “Effects of the Molecular
Weight and Concentration of Polymer Additives, and Temperature on the Melt
Crystallization Kinetics of a Small Drug Molecule”, Crystal Growth & Design 10(8), 3585-3595, 2010 (DOI: 10.1021/cg1004853).
17)
J. Hur, N. A.
Mahynski, Y.-Y. Won, “Crystallization of Bidisperse Repulsive Colloids in
Two-Dimensional Space: A Study of Model Systems Constructed at the Air-Water
Interface”, Langmuir 26(14),
11737-11749, 2010 (DOI: 10.1021/la101313r).
18)
K. N. Witte, S. Kewalramani, I. Kuzmenko, W.
Sun, M. Fukuto, Y.-Y. Won, “Formation and Collapse of Single-Monomer-Thick
Monolayers of Poly(n-Butyl Acrylate)
at the Air-Water Interface”, Macromolecules 43(6), 2990-3003, 2010 (DOI:
10.1021/ma901842q).
19)
J. Hur, K. N. Witte,
W. Sun, Y.-Y. Won, “On the Origins of the Salt-Concentration-Dependent
Instability and Lateral Nanoscale Heterogeneities of Weak Polyelectrolyte
Brushes: Gradient Brush Experiment, and Flory-Type Theoretical Analysis”, Langmuir 26(3),
2021-2034, 2010 (DOI: 10.1021/la902549b).
20)
Y.-Y. Won, R. Sharma, S. F. Konieczny,
“Missing Pieces in Understanding the Intracellular Trafficking of
Polycation/DNA Complexes”, Journal of
Controlled Release 139(2), 88-93, 2009 (DOI: 10.1016/j.jconrel.2009.06.031);
Journal of Controlled Release 152(2),
326, 2009 (DOI: 10.1016/j.jconrel.2011.04.003).
21)
K. N. Witte, S. Kim, Y.-Y. Won, “Self-Consistent
Field Theory Study of the Effect of Grafting Density on the Height of a Weak
Polyelectrolyte Brush”, Journal of
Physical Chemistry B 113(32),
11076-11084, 2009 (DOI: 10.1021/jp809814j).
22)
K. N. Witte, J. Hur, W. Sun, S. Kim, Y.-Y.
Won, “Evidence of Lateral Nanoscale Heterogeneities in Weak Polyelectrolyte
Brushes”, Macromolecules 41(23),
8960-8963, 2008 (DOI: 10.1021/ma801412u).
23)
R. Sharma, J.-S. Lee, R. C.
Bettencourt, C. Xiao, S. F. Konieczny, Y.-Y. Won, “Effects of the Incorporation of a Hydrophobic Middle Block into a
PEG-Polycation Diblock Copolymer on the Physicochemical and Cell Interaction
Properties of the Polymer-DNA Complexes”, Biomacromolecules 9(11), 3294-3307, 2008 (DOI: 10.1021/bm800876v).
24)
J. Hur, Y.-Y. Won, “Fabrication of High-Quality Non-Close-Packed 2D Colloid Crystals by
Template-Guided Langmuir-Blodgett (LB) Particle Deposition”, Soft Matter 4(6),
1261-1269, 2008 (DOI: 10.1039/b716218a). See "Self-assembling
Method Could Lead to Inexpensive Diamond-like Crystals for Technology"
in ScienceDaily (April 22, 2008). This article was one of the ten most
downloaded Soft Matter articles for April 2010 (http://www.rsc.org/publishing/journals/sm/top10.asp)
25)
J. Hur, Y.-Y. Won, “Two-Dimensional
Colloid Crystals Templated by Polyelectrolyte Multilayer Patterns”, Langmuir 24(10),
5382-5392, 2008 (DOI: 10.1021/la704050t).
26)
K. N. Witte, Y.-Y. Won, “Effect
of Interfacial Curvature on Mixed Polyelectrolyte and Neutral
Polymer Brushes: An SCF Numerical Analysis”, Macromolecules 41(7),
2735-2738, 2008 (DOI: 10.1021/ma071682e).
27)
Y. Zhao, M. T. Carvajal, Y.-Y. Won, M. T. Harris, “Preparation
of Calcium Alginate Microgel Beads by an Electrodispersion Reactor Using an
Internal Source of Calcium Carbonate Nanoparticles”, Langmuir 23(25), 12489-12496, 2007 (DOI: 10.1021/la701795y).
28)
D. Zhu, M.
A. Haidekker, J.-S. Lee, Y.-Y.
Won, J. C.-M. Lee, “Application
of Molecular Rotors to the Determination of the Molecular Weight-Dependence of
Viscosity in Polymer Melts”, Macromolecules 40(21), 7730-7732, 2007 (DOI: 10.1021/ma0702288).
29)
D. J. Gary, N. Puri, Y.-Y. Won,
“Polymer-Based siRNA Delivery: Perspectives on the Fundamental and
Phenomenological Distinctions from Polymer-Based DNA Delivery”, Journal of Controlled Release 121(1-2),
64-73, 2007 (DOI: 10.1016/j.jconrel.2007.05.021).
30)
K. N. Witte, Y.-Y. Won, “Self-Consistent Field (SCF) Analysis of Mixed
Polyelectrolyte and Neutral
Polymer Brushes”, Macromolecules 39(22), 7757-7768, 2006 (DOI: 10.1021/ma0608370).
31)
R. Sharma, A. Goyal, J. M. Caruthers, Y.-Y.
Won, “Inhibitive Chain Transfer
to Ligand in the ATRP of n-Butyl Acrylate”, Macromolecules 39(14),
4680-4689, 2006 (DOI: 10.1021/ma060374y).
32)
Y.-Y. Won, S. P. Meeker, V. Trappe, D. A.
Weitz, N. Z. Diggs, J. I. Emert, “Effect of Temperature on Carbon Black
Agglomeration in Hydrocarbon Liquid with Adsorbed Dispersant”, Langmuir 21(4),
924-932, 2005 (DOI: 10.1021/la047906t).
33)
P. E. Trapa, Y.-Y. Won, S. C. Mui, E. A.
Olivetti, B. Huang, D. R. Sadoway, A. M. Mayes, S. Dallek, “Rubbery
Graft Copolymer Electrolytes for Solid-State, Thin-Film Lithium Batteries”, Journal of the Electrochemical Society 152(1),
A1-A5, 2005 (DOI: 10.1149/1.1824032).
34)
Y.-Y. Won, “Imaging Nanostructured Fluids Using
Cryo-TEM”, Korean Journal of Chemical Engineering 21(1),
296-302, 2004 (DOI: 10.1007/BF02705412). This article has been
referenced in an STTR call from the US Army, titled “Nanoscale In-Solution TEM
Sample Stage with Manipulation Capability (A08-T029)”
(January 22, 2008).
35)
Y.-Y. Won, H. T. Davis, F. S. Bates,
“Molecular Exchange in PEO-PB Micelles in Water”, Macromolecules 36(3),
953-955, 2003 (DOI: 10.1021/ma021439+).
36)
M. M. Santore, D. E. Discher, Y.-Y. Won, F.
S. Bates, D. A. Hammer, “Effect of Surfactant on Unilamellar Polymeric
Vesicles: Altered Membrane Properties and Stability in the Limit of Weak
Surfactant Partitioning”, Langmuir 18(20),
7299-7308, 2002 (DOI: 10.1021/la0201319).
37)
J. F. Hester, P. Banergee, Y.-Y. Won, A.
Akthakul, M. H. Acar, A. M. Mayes, “ATRP of Amphiphilic Graft Copolymers Based
on PVDF and Their Use as Membrane Additives”, Macromolecules 35(20),
7652-7661, 2002 (DOI: 10.1021/ma0122270).
38)
P. E. Trapa, B. Huang, Y.-Y. Won, D. R.
Sadoway, A. M. Mayes, “Block Copolymer Electrolytes Synthesized by Atom
Transfer Radical Polymerization for Solid-State, Thin-Film Lithium Batteries”, Electrochemical
and Solid-State Letters 5(5),
A85-A88, 2002 (DOI: 10.1149/1.1461996).
39)
Y.-Y. Won, A. K. Brannan, H. T. Davis, F. S.
Bates, “Cryogenic Transmission Electron Microscopy (Cryo-TEM) of Micelles and
Vesicles Formed in Water by Poly(ethylene oxide)-based Block Copolymers”, Journal
of Physical Chemistry B 106(13),
3354-3364, 2002 (DOI: 10.1021/jp013639d).
40)
B. M. Discher, H. Bermudez, D. A. Hammer, D.
E. Discher, Y.-Y. Won, F. S. Bates, “Crosslinked Polymersome Membranes:
Vesicles with Broadly Adjustable Stability”, Journal of Physical Chemistry B 106(11),
2848-2854, 2002 (DOI: 10.1021/jp011958z).
41)
Y.-Y. Won, K. Paso, H. T. Davis, F. S. Bates,
“Comparison of Original and Cross-linked Wormlike Micelles of Poly(ethylene
oxide-b-butadiene) in Water: Rheological Properties and Effects of Poly(ethylene
oxide) Addition”, Journal of Physical Chemistry B 105(35),
8302-8311, 2001 (DOI: 10.1021/jp004078d).
42)
J. C.-M. Lee, H. Bermudez, B. M. Discher, M.
Sheehan, Y.-Y. Won, F. S. Bates, D. E. Discher, “Preparation, Stability, and In Vitro Performance of
Vesicles Made from Diblock Copolymers”, Biotechnology and Bioengineering 73(2),
135-145, 2001 (DOI: 10.1002/bit.1045).
43)
B. Jeong, M. R. Kibbey, J. C. Birnbaum, Y.-Y.
Won, A. Gutowska, “Thermogelling Biodegradable Polymers with Hydrophilic
Backbones: PEG-g-PLGA”, Macromolecules 33(22),
8317-8322, 2000 (DOI: 10.1021/ma000638v).
44)
Y.-Y. Won, H. T. Davis, F. S. Bates, M.
Agamalian, G. D. Wignall, “Segment Distribution of the Micellar Brushes of
Poly(ethylene oxide) via Small-Angle Neutron Scattering”, Journal of
Physical Chemistry B 104(30),
7134-7143 (DOI: 10.1021/jp000457v), 2000; Journal of Physical Chemistry
B 104(38), 9054-9054, 2000 (DOI:
10.1021/jp002934f).
45)
Y. Zheng, Y.-Y. Won, F. S. Bates, H. T.
Davis, L. E. Scriven, Y. Talmon, “Directly Resolved Core-Corona Structure of
Block Copolymer Micelles by Cryo-Transmission Electron Microscopy”, Journal
of Physical Chemistry B 103(47),
10331-10334, 1999 (DOI: 10.1021/jp9923264).
46)
B. M. Discher, Y.-Y. Won, J. C.-M. Lee, J.
Eggs, F. S. Bates, D. E. Discher, D. A. Hammer, “Polymersomes: Vesicles Made
from Diblock Copolymers”, Science 284 (5417),
1143-1146, 1999 (DOI: 10.1126/science.284.5417.1143).
47)
Y.-Y. Won, H. T. Davis, F. S. Bates, “Giant
Wormlike Rubber Micelles”, Science 283 (5404),
960-963, 1999 (DOI: 10.1126/science.283.5404.960).
1)
Y.-Y. Won, F. S. Bates, “Nonionic Block Copolymer
Wormlike Micelles”, in Giant Micelles:
Properties and Applications (Editors: R. Zana, E. W. Kaler), CRC
Press/Taylor & Francis, Boca Raton, FL, 2007.
PATENTS
1)
“Block Copolymer (BCP) Encapsulated
Nanoparticles and Methods of Use Thereof”, Y.-Y. Won, D. H. Kim, R. P. Andres,
pending U.S. Patent,
Application No. 13/837,705, PRF Reference No. 66166-02, filed March 15, 2013.
2)
“Cross-linked Polymersomes and Related Encapsulating
Membranes”, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, pending U.S. Patent,
U.S. Patent No. 7,867,512,
filed February 20, 2007, issued January 11, 2011.
3)
“Polymersomes and Related Encapsulating
Membranes”, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, U.S. Patent No.
7,217,427 B2, filed July 1, 2004, issued May 15, 2007.
4)
“Polymersomes and Related Encapsulating
Membranes”, D. E. Discher, B. M. Discher, Y.-Y. Won, J. C.-M. Lee, F. S. Bates,
D. A. Hammer, U.S. Patent No. 6,835,394, filed
December 14, 1999, issued December 28, 2004.